The role of cardiac magnetic resonance-based feature-tracking strain analysis in the differential diagnosis and prognostic assessment of patients with left ventricular hypertrophy

Abstract Background Cardiac magnetic resonance (CMR) examinations have an essential role in the diagnosis of myocardial diseases with left ventricular (LV) hypertrophy; however, limited data are available from CMR-based feature-tracking strain analysis this patient population. The aim our study was to investigate differential diagnostic and prognostic importance patients LV hypertrophy caused by disease. Methods We investigated 404 who underwent CMR examination were diagnosed disease causing hypertrophy. Hypertrophic cardiomyopathy (HCM) detected 330 patients, cardiac amyloidosis (CA) 46 Fabry (FD) 12 endomyocardial fibrosis (EMF) 16 patients. performed feature-tracking. Global longitudinal (GLS), circumferential (GCS) radial (GRS) parameters measured. Strain values for six basal, midventricular, five apical segments averaged obtain regional (basal LS, midventricular basal CS, CS). apex-to-base LS CS ratios calculated as LS/basal CS/basal respectively. To assess global dyssynchrony, mechanical dispersion (MD) all-cause mortality analyzed. Results In differentiation CA HCM, GLS had highest sensitivity a cutoff more than −23%, specificity −16% −38%, respectively (p<0.001). FD lowest MD values, meaning that compared other hypertrophy, dyssynchrony is least pronounced population (p<0.01). EMF impaired ratios. ratios, suggestive sparing worst prognosis; significant independent predictors CA, stroke volume index Conclusions Myocardial remarkable differences characteristics which can be helpful provides incremental information on adverse outcomes. Funding Acknowledgement Type funding sources: Public grant(s) – National budget only. Main source(s): Development Innovation Fund Hungary, Ministry Technology Hungary